- Adult patients, 18 years or older with acne vulgaris, were administered 1 single dose of oral minocycline extended-release tablets dosed 1 mg/kg
- Following a 10-day wash-out period, patients then began topical Amzeeq 4% therapy dosed 4 g/day (8x the recommended dose in clinical trials) applied for 21 days†
- The overall pediatric population showed 2.4-fold and 2.7-fold higher Cmax and AUCO-24h compared to the adult population
There were no significant differences in the minocycline
pharmacokinetics within the pediatric population among
10 yearsto less than 17 years of age with acne vulgaris
- †Blood samples were obtained before and after administration of oral minocycline and each topical application of Amzeeq 4% on days 1, 12, and 21.